Day: April 4, 2021

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical query of how water particularly crosses organic membranes. In the kidney, no less than seven aquaporins are expressed at distinct websites. AQP1 is extraordinarily ample in the proximal tubule and descending skinny limb and is crucial for urinary focus. AQP2 is solely expressed in the principal…

Cerebral edema contributes considerably to morbidity and loss of life related to many frequent neurological issues. However, present remedy choices are restricted to hyperosmolar brokers and surgical decompression, therapies launched greater than 70 years in the past. Here we present that mice poor in aquaporin-4 (AQP4), a glial membrane water channel, have a lot better…